26 research outputs found
Multiwavelength Study on Solar and Interplanetary Origins of the Strongest Geomagnetic Storm of Solar Cycle 23
We study the solar sources of an intense geomagnetic storm of solar cycle 23
that occurred on 20 November 2003, based on ground- and space-based
multiwavelength observations. The coronal mass ejections (CMEs) responsible for
the above geomagnetic storm originated from the super-active region NOAA 10501.
We investigate the H-alpha observations of the flare events made with a 15 cm
solar tower telescope at ARIES, Nainital, India. The propagation
characteristics of the CMEs have been derived from the three-dimensional images
of the solar wind (i.e., density and speed) obtained from the interplanetary
scintillation data, supplemented with other ground- and space-based
measurements. The TRACE, SXI and H-alpha observations revealed two successive
ejections (of speeds ~350 and ~100 km/s), originating from the same filament
channel, which were associated with two high speed CMEs (~1223 and ~1660 km/s,
respectively). These two ejections generated propagating fast shock waves
(i.e., fast drifting type II radio bursts) in the corona. The interaction of
these CMEs along the Sun-Earth line has led to the severity of the storm.
According to our investigation, the interplanetary medium consisted of two
merging magnetic clouds (MCs) that preserved their identity during their
propagation. These magnetic clouds made the interplanetary magnetic field (IMF)
southward for a long time, which reconnected with the geomagnetic field,
resulting the super-storm (Dst_peak=-472 nT) on the Earth.Comment: 24 pages, 16 figures, Accepted for publication in Solar Physic
Randomized multicentre pilot study of sacubitril/valsartan versus irbesartan in patients with chronic kidney disease: United Kingdom Heart and Renal Protection (HARP)- III—rationale, trial design and baseline data
BACKGROUND:
Patients with chronic kidney disease (CKD) are at risk of progression to end-stage renal disease and cardiovascular disease. Data from other populations and animal experiments suggest that neprilysin inhibition (which augments the natriuretic peptide system) may reduce these risks, but clinical trials among patients with CKD are required to test this hypothesis.
METHODS:
UK Heart and Renal Protection III (HARP-III) is a multicentre, double-blind, randomized controlled trial comparing sacubitril/valsartan 97/103 mg two times daily (an angiotensin receptor-neprilysin inhibitor) with irbesartan 300 mg one time daily among 414 patients with CKD. Patients ≥18 years of age with an estimated glomerular filtration rate (eGFR) of ≥45 but <60 mL/min/1.73 m2 and urine albumin:creatinine ratio (uACR) >20 mg/mmol or eGFR ≥20 but <45 mL/min/1.73 m2 (regardless of uACR) were invited to be screened. Following a 4- to 7-week pre-randomization single-blind placebo run-in phase (during which any current renin-angiotensin system inhibitors were stopped), willing and eligible participants were randomly assigned either sacubitril/valsartan or irbesartan and followed-up for 12 months. The primary aim was to compare the effects of sacubitril/valsartan and irbesartan on measured GFR after 12 months of therapy. Important secondary outcomes include effects on albuminuria, change in eGFR over time and the safety and tolerability of sacubitril/valsartan in CKD.
RESULTS:
Between November 2014 and January 2016, 620 patients attended a screening visit and 566 (91%) entered the pre-randomization run-in phase. Of these, 414 (73%) participants were randomized (mean age 63 years; 72% male). The mean eGFR was 34.0 mL/min/1.73 m2 and the median uACR was 58.5 mg/mmol.
CONCLUSIONS:
UK HARP-III will provide important information on the short-term effects of sacubitril/valsartan on renal function, tolerability and safety among patients with CKD
Atmospheric Heating and Wind Acceleration: Results for Cool Evolved Stars based on Proposed Processes
A chromosphere is a universal attribute of stars of spectral type later than
~F5. Evolved (K and M) giants and supergiants (including the zeta Aurigae
binaries) show extended and highly turbulent chromospheres, which develop into
slow massive winds. The associated continuous mass loss has a significant
impact on stellar evolution, and thence on the chemical evolution of galaxies.
Yet despite the fundamental importance of those winds in astrophysics, the
question of their origin(s) remains unsolved. What sources heat a chromosphere?
What is the role of the chromosphere in the formation of stellar winds? This
chapter provides a review of the observational requirements and theoretical
approaches for modeling chromospheric heating and the acceleration of winds in
single cool, evolved stars and in eclipsing binary stars, including physical
models that have recently been proposed. It describes the successes that have
been achieved so far by invoking acoustic and MHD waves to provide a physical
description of plasma heating and wind acceleration, and discusses the
challenges that still remain.Comment: 46 pages, 9 figures, 1 table; modified and unedited manuscript;
accepted version to appear in: Giants of Eclipse, eds. E. Griffin and T. Ake
(Berlin: Springer
Origins of the Ambient Solar Wind: Implications for Space Weather
The Sun's outer atmosphere is heated to temperatures of millions of degrees,
and solar plasma flows out into interplanetary space at supersonic speeds. This
paper reviews our current understanding of these interrelated problems: coronal
heating and the acceleration of the ambient solar wind. We also discuss where
the community stands in its ability to forecast how variations in the solar
wind (i.e., fast and slow wind streams) impact the Earth. Although the last few
decades have seen significant progress in observations and modeling, we still
do not have a complete understanding of the relevant physical processes, nor do
we have a quantitatively precise census of which coronal structures contribute
to specific types of solar wind. Fast streams are known to be connected to the
central regions of large coronal holes. Slow streams, however, appear to come
from a wide range of sources, including streamers, pseudostreamers, coronal
loops, active regions, and coronal hole boundaries. Complicating our
understanding even more is the fact that processes such as turbulence,
stream-stream interactions, and Coulomb collisions can make it difficult to
unambiguously map a parcel measured at 1 AU back down to its coronal source. We
also review recent progress -- in theoretical modeling, observational data
analysis, and forecasting techniques that sit at the interface between data and
theory -- that gives us hope that the above problems are indeed solvable.Comment: Accepted for publication in Space Science Reviews. Special issue
connected with a 2016 ISSI workshop on "The Scientific Foundations of Space
Weather." 44 pages, 9 figure
Solar parameters for modeling interplanetary background
The goal of the Fully Online Datacenter of Ultraviolet Emissions (FONDUE)
Working Team of the International Space Science Institute in Bern, Switzerland,
was to establish a common calibration of various UV and EUV heliospheric
observations, both spectroscopic and photometric. Realization of this goal
required an up-to-date model of spatial distribution of neutral interstellar
hydrogen in the heliosphere, and to that end, a credible model of the radiation
pressure and ionization processes was needed. This chapter describes the solar
factors shaping the distribution of neutral interstellar H in the heliosphere.
Presented are the solar Lyman-alpha flux and the solar Lyman-alpha resonant
radiation pressure force acting on neutral H atoms in the heliosphere, solar
EUV radiation and the photoionization of heliospheric hydrogen, and their
evolution in time and the still hypothetical variation with heliolatitude.
Further, solar wind and its evolution with solar activity is presented in the
context of the charge exchange ionization of heliospheric hydrogen, and in the
context of dynamic pressure variations. Also the electron ionization and its
variation with time, heliolatitude, and solar distance is presented. After a
review of all of those topics, we present an interim model of solar wind and
the other solar factors based on up-to-date in situ and remote sensing
observations of solar wind. Results of this effort will further be utilised to
improve on the model of solar wind evolution, which will be an invaluable asset
in all heliospheric measurements, including, among others, the observations of
Energetic Neutral Atoms by the Interstellar Boundary Explorer (IBEX).Comment: Chapter 2 in the planned "Cross-Calibration of Past and Present Far
UV Spectra of Solar System Objects and the Heliosphere", ISSI Scientific
Report No 12, ed. R.M. Bonnet, E. Quemerais, M. Snow, Springe
Supplementary Material for: Outcomes of Elderly Patients with Anti-Neutrophil Cytoplasmic Autoantibody-Associated Vasculitis Treated with Immunosuppressive Therapy
<i>Background/Aims:</i> Anti-neutrophil cytoplasmic autoantibody-associated vasculitis (AAV) is a cause of biopsy-proven acute kidney injury, more common in the elderly. Treatment requires immunosuppression, which can have significant toxic effects. The aim of this study was to assess whether morbidity and mortality that are associated with immunosuppression for AAV varied with age. <i>Methods:</i> A retrospective review of 232 patients given induction therapy with prednisolone and cyclophosphamide was conducted. Information was collected on baseline characteristics (including requirement for dialysis at presentation) and the occurrence of leukopenia, infection, end-stage renal disease and death during follow-up. <i>Results:</i> Median follow-up was 51 months. Older patients (aged ≥70 years) were treated with lower total cyclophosphamide doses than those aged <70 years (mean 7.3 g (SD 4.4) vs. 10.7 g (SD 7.4), respectively). Increasing age was associated with an increased risk of leukopenia (odds ratio (OR) 1.50; 95% confidence interval (CI) 1.20-1.86; p < 0.001), and older patients were more likely to develop infections in the first year (OR 1.87; 95% CI 1.1-3.2). Older patients were also significantly more likely to require dialysis at presentation (OR 1.66; 95% CI 1.13-2.5) and longer term. After multivariable adjustment, age and requirement for dialysis at presentation were significant predictors of death (hazard ratio (HR) per year of age 1.07; 95% CI 1.03-1.11; p < 0.001 and HR 2.2; 95% CI 1.10-4.38; p = 0.03, respectively). <i>Conclusions:</i> Among patients treated with prednisolone and cyclophosphamide, increasing age and dialysis dependency were associated with worse survival. Older patients were more likely to develop treatment-related complications despite lower cumulative doses of immunosuppression. Morbidity and mortality associated with treatment must therefore be carefully balanced against that associated with the disease process itself